Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, et al.
) that represents the oldest form of pharmacotherapy in PE (1943).
The role of local anaesthetics in premature ejaculation. The use of drugs that selectively reduce penile sensitization or which modify the afferent-efferent reflex could provide effective therapy for PE, as has been shown with the off-label use of topical desensitizing creams ( 1 1. The authors discussed advantages and disadvantages of currently available off-label and officially approved treatment options and presented the dose-metered lidocaine-prilocaine spray (Fortacin™), the first topical treatment to be officially approved in Europe for the treatment of primary PE in adult men. The only so far officially approved medication – dapoxetine - is characterized by high discontinuation rates of up to 90%, mostly because of high side effects, cost issues, efficacy below expectations, and the need for scheduling sexual intercourse. Hartmut Porst and Andrea Burri pointed the actual situation of Premature Ejaculation (PE) arguing that there is a gap between what doctors are prescribing and what patients expect from treatment. 1 European Institute for Sexual Health (EISH), Hamburg, Germany 2 European Institute for Sexual Health (EISH), Hamburg, GermanyĭOI: 10.1016/j.sxmr.2018.05.001 | ACCESS: 10.1016/j.sxmr.2018.05.001 COMMENT
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